{"claims": [{"text": "Epilepsy affects more than 50 million people worldwide", "quote_or_locator": "Abstract, opening sentence: 'Epilepsy is one of the most common neurological disorders, affecting more than 50 million people worldwide.'"}, {"text": "Loss-of-function mutations in voltage-gated sodium channels can result in a wide range of phenotypes including West syndrome, autism spectrum disorder, or Dravet Syndrome", "quote_or_locator": "Abstract: 'loss-of-function (LoF) mutations voltage-gated sodium (NaV) can result a wide range phenotypes including West syndrome, autism spectrum disorder, or Dravet Syndrome.'"}, {"text": "Subtype-specific downregulations did not produce uniform phenotype; minor differences led to important discrepancies in response to inflammatory stimulus", "quote_or_locator": "Abstract: 'Subtype-specific downregulations did not produce uniform phenotype. Rather, minor differences led important discrepancies exposure stimulus.'"}, {"text": "NaV1.1 reduction was associated with synaptic and transcriptional changes", "quote_or_locator": "Abstract: 'NaV1.1 reduction was associated synaptic transcriptional changes'"}, {"text": "NaV1.2 reduction showed substantial signaling remodeling", "quote_or_locator": "Abstract: 'whereas substantial signaling remodeling' [in context of NaV1.2 downregulation]"}, {"text": "The study used shRNA-mediated silencing of Scn1a, Scn2a, and Scn8a in primary mouse cortical neurons", "quote_or_locator": "Abstract: 'Using shRNA-mediated silencing Scn1a, Scn2a, Scn8a, generated cultures with reduced NaV1.1, NaV1.2, NaV1.6'"}], "prompt_version": "p1.0"}