{"claims": [{"text": "Baseline cohort had 1,055 patients with average age 63.5 years and MDS-UPDRS III score of 22.9", "quote_or_locator": "Results section: 'On the baseline cohort (63.5 ± 9.5 years, MDS-UPDRS III: 22.9 ± 11.0)'"}, {"text": "Follow-up cohort had 652 patients, median 2.2 years post-enrollment", "quote_or_locator": "Methods section: 'a cohort built from non-baseline visits (median 2.2 years post-enrollment, N=652)'"}, {"text": "Bradykinesia and rigidity showed large contralateral correlations with striatal binding, correlation coefficients between minus 0.20 and minus 0.38, all p less than 0.05", "quote_or_locator": "Results section: 'bradykinesia and rigidity showed, as expected, large contralateral correlations with striatal binding that were far outside the permutation null in caudate and putamen (ρ –0.20 to –0.38; all p<0.05)'"}, {"text": "Rest tremor showed modest positive ipsilateral correlations of plus 0.11 to plus 0.22, all p greater than 0.05", "quote_or_locator": "Results section: 'Rest tremor showed a different pattern instead: modest positive ipsilateral correlations that are within the null distribution (ρ +0.11 to +0.22, all p>0.05)'"}, {"text": "Rest tremor presence was predicted from binding with AUC 0.55 to 0.61", "quote_or_locator": "Results section: 'rest tremor's presence was predicted from binding on either side, in 7 of 8 comparisons (Figure 2A, logistic regression AUC 0.55–0.61; p<0.01)'"}, {"text": "Rest tremor severity among affected patients was not predicted by any comparison with R-squared less than or equal to 0.002", "quote_or_locator": "Results section: 'Its severity among affected patients, by contrast, was not predicted by any comparison (R² ≤ 0.002).'"}, {"text": "Bradykinesia contralateral putamen binding predicted presence with AUC 0.65 to 0.74 and severity with R-squared 0.015 to 0.056", "quote_or_locator": "Results section: 'bradykinesia showed the opposite pattern: contralateral putamen binding predicted presence (Figure 2B, AUC 0.65–0.74, p<0.001 in all comparisons) and severity (R² 0.015–0.056, p<0.001 in all comparisons)'"}, {"text": "Permutation test used 10,000 permutations with Benjamini-Hochberg false discovery rate correction", "quote_or_locator": "Methods section: 'randomly permuting severity values among symptom-positive patients (10,000 permutations, two-sided). Statistical significance was defined at α =0.05, with Benjamini-Hochberg false discovery rate (FDR) procedure for multiple comparisons.'"}, {"text": "Rest tremor's ipsilateral correlation was not distinguishable from the permutation null in most comparisons", "quote_or_locator": "Results section: 'Unlike bradykinesia's and rigidity's contralateral correlations, rest tremor's ipsilateral correlation was significantly different from zero by conventional testing, yet not distinguishable from the permutation null in most comparisons'"}], "prompt_version": "p1.0", "verdicts": [{"claim": "Baseline cohort had 1,055 patients with average age 63.5 years and MDS-UPDRS III score of 22.9", "verdict": "supported", "evidence": "On the baseline cohort (63.5 ± 9.5 years, MDS-UPDRS III: 22.9 ± 11.0)", "note": null}, {"claim": "Follow-up cohort had 652 patients, median 2.2 years post-enrollment", "verdict": "supported", "evidence": "a cohort built from non-baseline visits (median 2.2 years post-enrollment, N=652)", "note": null}, {"claim": "Bradykinesia and rigidity showed large contralateral correlations with striatal binding, correlation coefficients between minus 0.20 and minus 0.38, all p less than 0.05", "verdict": "supported", "evidence": "bradykinesia and rigidity showed, as expected, large contralateral correlations with striatal binding that were far outside the permutation null in caudate and putamen (ρ –0.20 to –0.38; all p<0.05)", "note": null}, {"claim": "Rest tremor showed modest positive ipsilateral correlations of plus 0.11 to plus 0.22, all p greater than 0.05", "verdict": "supported", "evidence": "Rest tremor showed a different pattern instead: modest positive ipsilateral correlations that are within the null distribution (ρ +0.11 to +0.22, all p>0.05)", "note": null}, {"claim": "Rest tremor presence was predicted from binding with AUC 0.55 to 0.61", "verdict": "supported", "evidence": "rest tremor's presence was predicted from binding on either side, in 7 of 8 comparisons (Figure 2A, logistic regression AUC 0.55–0.61; p<0.01)", "note": null}, {"claim": "Rest tremor severity among affected patients was not predicted by any comparison with R-squared less than or equal to 0.002", "verdict": "supported", "evidence": "Its severity among affected patients, by contrast, was not predicted by any comparison (R² ≤ 0.002).", "note": null}, {"claim": "Bradykinesia contralateral putamen binding predicted presence with AUC 0.65 to 0.74 and severity with R-squared 0.015 to 0.056", "verdict": "supported", "evidence": "bradykinesia showed the opposite pattern: contralateral putamen binding predicted presence (Figure 2B, AUC 0.65–0.74, p<0.001 in all comparisons) and severity (R² 0.015–0.056, p<0.001 in all comparisons)", "note": null}, {"claim": "Permutation test used 10,000 permutations with Benjamini-Hochberg false discovery rate correction", "verdict": "supported", "evidence": "randomly permuting severity values among symptom-positive patients (10,000 permutations, two-sided). Statistical significance was defined at α =0.05, with Benjamini-Hochberg false discovery rate (FDR) procedure for multiple comparisons.", "note": null}, {"claim": "Rest tremor's ipsilateral correlation was not distinguishable from the permutation null in most comparisons", "verdict": "supported", "evidence": "Unlike bradykinesia's and rigidity's contralateral correlations, rest tremor's ipsilateral correlation was significantly different from zero by conventional testing, yet not distinguishable from the permutation null in most comparisons", "note": null}]}