{"claims": [{"text": "Experience-dependent structural plasticity is prominent in juvenile circuits during critical periods of development but drastically decreases in adult circuits.", "quote_or_locator": "Abstract: 'Experience-dependent is prominent juvenile circuits during critical periods development but drastically decreases adult circuits.'"}, {"text": "SRGAP2 is a postsynaptic protein that limits both excitatory and inhibitory synapses in pyramidal neurons during development and promotes their maturation.", "quote_or_locator": "Abstract: 'postsynaptic protein SRGAP2 limits both excitatory (E) inhibitory (I) synapses pyramidal neurons (CPNs) promotes their maturation.'"}, {"text": "In SRGAP2+/- mice, sensory deprivation (whisker trimming) induced a striking increase in structural plasticity, whereas in wild-type mice whisker trimming did not induce significant remodeling.", "quote_or_locator": "Abstract: 'Using longitudinal 2-photon (2P) imaging dendritic spine dynamics layer 2/3 CPNs found that this form sensory deprivation induces a striking increase favoring constitutive SRGAP2+/- mice, contrast wild-type where whisker trimming does induce significant [change]'"}, {"text": "The effect of SRGAP2 deletion on structural plasticity requires layer 2/3 microglia.", "quote_or_locator": "Abstract: 'conditional, cell-type specific, deletion SRGAP2, we demonstrate requires L2/3 microglia.'"}, {"text": "Human-specific SRGAP2 paralogs SRGAP2B and SRGAP2C inhibit all known functions of SRGAP2, phenocopying haploinsufficiency.", "quote_or_locator": "Abstract: 'human-specific paralogs SRGAP2B/C inhibit all known functions phenocopying haploinsufficiency'"}, {"text": "The results suggest human-specific SRGAP2 variants might endow increased levels of plasticity in adult human cortex.", "quote_or_locator": "Abstract: 'our results suggest might endow increased levels human [plasticity]'"}], "prompt_version": "p1.0"}